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Clomid Challenge Test – A Fertility Test for Women

A clomid challenge test is a fertility test for women, which my infertility doctor asked me to do. Clomid is the brand name, and clomiphene citrate is the generic name. This fertility test assesses a woman’s ovarian “reserve” and functioning. Here are the basics of a clomid challenge test — which is a relatively simple test for infertility.

“There’s no point in wasting money on in vitro fertilization or intrauterine insemination if you can’t get pregnant,” says my fertility doctor. “This fertility test will tell us what your follicle stimulating hormone (FSH) levels are, which will tell us if you can conceive a baby.”

In two years of fertility treatments, this is the first time a doctor has suggested this test for infertility (we’re trying a new fertility clinic). Here’s what the clomiphene challenge test is all about.

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Clomid Challenge Test – A Fertility Test for Women

Two blood tests, a prescription for clomiphene citrate (Serophene is the brand name of the medication my doctor prescribed, but Clomid is also popular), and five days of medication are what this female fertility test involves…

Blood tests are done before and after taking clomiphene citrate for five days. This medication stimulates the ovaries to produce extra estrogen; the results of the blood tests provide information about egg quality and quantity. This info – egg quality and quantity – indicated whether I can actually get pregnant. It provides more information on when (and if) I’m ovulating. Basically, the clomid challenge tests gives info about ovarian functioning.

As with many infertility tests for women, the clomiphene challenge test revolves around menstruation. Thankfully, my periods are regular! If you’re dealing with irregular periods, read 6 Things That Cause Irregular Periods.

On cycle day three of my period, I have my blood tested for follicle stimulating hormone levels and estradiol.

Then, I start the clomid tablets on cycle day five, and take two a day for five days. Serphone or clomiphene citrate regulates hormonal secretion, increases estrogen, and triggers a series of events that end in ovulation. Basically, clomid increases estrogen production.

On cycle day ten of my period, I go for a second blood test, to test my FSH levels. If my FSH is above 12, then my ovulation cycle is abnormal and I won’t be able to get pregnant. The fertility doctor said an FSH level of below 10 is ideal.

And that’s it for this test for infertility! I’m surprised I haven’t been asked to do this test before – we’ve been to other different fertility clinics, and neither mentioned the clomid challenge test.

The first fertility clinic did six cycles of intrauterine insemination (IUI), and I didn’t get pregnant. The second fertility clinic wanted to do in vitro fertilization and take out my fibroid with surgery (the fibroid doesn’t hurt, and I didn’t even know I had it). Neither mentioned my follicle stimulating hormone or FSH levels….and I’m can’t wait to find out if I went through all that IUI for nothing.

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If you have any thoughts on this clomid challenge test or fertility tests for women, I welcome your comments below…

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7 thoughts on “Clomid Challenge Test – A Fertility Test for Women”

  1. Hi Byola,

    I’m not sure if a doctor has to administer the clomid challenge test – I think it depends where you live. If you want to take it, talk to your GP or fertility doctor and request it.

    Do you have to pay for it? That’s another question. Mine was paid for by our health insurance, but I suspect not all insurance covers it!

  2. Laurie Pawlik-Kienlen

    The medication was no problem — I was a bit emotional and moody, but that could’ve just been because of the stress of trying to get pregnant! I didn’t notice any side effects, other than that.

    I can’t remember when I ovulated that month…but I did learn that my cycles and hormones and all the rest of it were normal. We can’t get pregnant because of male infertility issues.

    I never did get pregnant — I don’t want to try in vitro fertilization. We did IUI for six months, and that was enough for me!

    Good luck, Kii….I hope all goes well, and you get pregnant soon. Let me know how it goes!


  3. I would be interested in knowing how your clomifen challenging test went. Did you respond well to the medication? When did you ovulate that month?

    I’m about to take the same test and am just frustrated in advance not to respond well to clomifen due to high fsh..