Is Trifexis a Safe Flea Treatment for Dogs?

Before you get the flea treatment Trifexis from your veterinarian, find out if it’s a safe flea treatment for dogs. Here are two stories of what happened when Trifexis was prescribed to dogs.

trifexis safe flea treatment for dogsI have given my dogs Bayer Topical Flea Treatment for Dogs with much better results, because of what happened when I gave my dog Georgie Trifexis flea treatment.

When you’re searching for a good flea treatment, remember that all dogs are different. My dog has a type of intestinal bowel disorder, which I describe in Causes of Gurgling Noises and Stomach Problems in Dogs. That’s why I can’t use Trifexis as a flea treatment for her. But, your dog’s stomach, genetics, and health is different than Georgie’s – and you may find that Trifexis is a safe flea treatment for your dog.






You don’t want fleas or ticks – nor do you want a sick dog – but an infestation of fleas isn’t necessarily the worst thing to happen to you and your dog. Death or worst health problems would be worse for your dog than fleas or ticks, which is why you need to research if Trifexis is a safe flea treatment for dogs.

Here’s how Trifexis (a flea treatment that isn’t natural) affected my dog Georgie and Julie Anne’s dog Kolbe. Julie Anne’s experience was much worse than mine. Her dog died, and she believes Trifexis contributed or possibly even caused Kolbe’s death. She’s dealing with guilt over her dog’s death – which is why it’s so important for you to research if Trifexis is a good flea treatment for your dog.

Is Trifexis a Safe Flea Treatment for Dogs?

It’s important to do your research before giving your dog any type of flea treatment – even natural, “safe” flea treatments and even if a veterinarian prescribes it. This is what trips me up every time! I assume that if a veterinarian is prescribing a medication – especially for something as “little” as preventing fleas and ticks – then it’s a safe treatment for my dog.

But I found out the hard way that Trifexis isn’t a good flea treatment for all dogs.

My dog Georgie and Trifexis

Georgie has irritable bowel syndrome (IBS), so I’m very careful about what food and medications she takes. When the IBS flares, she doesn’t eat and I can hear her stomach and guts make all kinds of noise. She also gets lethargic and listless. I was reluctant to give her Trifexis because I thought it was a synthetic-chemical flea treatment, but the veterinarian said it probably wouldn’t cause a flare up.

The veterinarian was wrong. Georgie was sick for three days after taking Trifexis, which I now believe is not a good or safe flea treatment for dogs. I thought her illness was because she was a sensitive stomach and bowels, but after hearing Julie Anne’s story, I now believe Trifexis is a potentially lethal medication for dogs.

Julie Anne’s dog and Trifexis

In Julie Anne’s words, here’s how Trifexis flea treatment affected her dog:

safe flea treatments for dog trifexisTrifexis Kills were the words that leapt out at me after searching the Internet about the cause for the recent death of our 10 year old Golden Retriever. On Friday, we went to the veterinarian with a slight cough.  We were given an antibiotic and a cough expectorant and the veterinarian said he would be as good as new in 10 days.  It was a respiratory infection that was confirmed by an x-ray.

On the weekend Kolbe was lethargic and not his usual self but the cough seemed to subside.  He did not want to go for his walk, and we let him rest. On Monday, the vet added Lasix to the prescribed flea treatment because Kolbe seemed to have trouble breathing.  By Monday night Kolbe could not lie down and was panting heavily.  We rushed him to the veterinarian on Tuesday morning.  It was now diagnosed as pneumonia and anemia. Kolbe was hospitalized and given IV medication.







The veterinarian was still hopeful our dog could be home by Friday.  On Wednesday morning he bled out and passed away.  The veterinarian said it was not what he anticipated.  After being given a clean bill of health in April with a wellness panel to prove it, we were devastated.

If you’ve experienced something similar, read How to Forgive Yourself for Not Protecting Your Dog.

How other dogs responded to Trifexis

For three weeks I searched the internet to find out if Trifexis is a good or safe flea treatment for dogs, and found story after story like mine about dogs who were perfectly healthy before starting on the heartworm prevention/flea protection medicine, Trifexis.

Is Trifexis a Safe Flea Treatment for Dogs

My dog Georgie – a terrier

I contacted our veterinarian, who has pulled the medication from their shelves. I also contacted the manufacturing company, Elanco, the FDA, and a consumer protection agency.  There was no autopsy on Kolbe, so the veterinarian representing Elanco said Trifexis was not responsible for our dog’s death.  There are hundreds of anecdotal stories about whether Trifexis is a good flea treatment for dogs on the Internet.

What if Trifexis kills your dog?

I feel sad and guilty that I did not look on the Internet before giving my wonderful dog Trifexis. Kolbe was the one who made us laugh every day.  He was a silly, kind, gentle soul that loved walking with me and his best canine friend, Murphy.  He was the one that knew exactly how to behave around my fragile 87 year old mom even though he could still do wild puppy like laps around the backyard when he pleased.  He was the only Golden Retriever that took very good care of his toys.  No squeakectomies for his stuffed toys! He had lived with other families for the first five years of his life, and then he marched into our family and our hearts and stayed for five years and a few months.  He was a great dog and we loved him dearly.  He was an important part of our family.

That’s Julie Anne’s story of how a seemingly innocent flea treatment can be fatal for dogs. If your dog died because of a medication like Trifexis, read Surviving the Death of a Dog.

It’s scary, because hundreds of veterinarians prescribe Trifexis as a good flea treatment for dogs. How do you know if it will negatively affect your dog? I’m going to ask veterinarians this question on Twitter and Facebook, and post their thoughts below.

trifexis good flea treatment for dogsIn addition to the flea treatment at the top of this article, I’ve also found K9 Advantix Flea Control for Dogs – it’s topical (I put it on the back of Georgie’s neck once a month), and has no side effects. I don’t think it’s a natural flea treatment, but Georgie doesn’t have fleas, ticks, or worms so I think it works! My veterinarian also recommended Revolution as a good flea treatment for dogs.

The tricky thing is that a flea treatment that works for one dog could potentially kill another dog. This makes it difficult to know which flea treatment is safe or good for dogs – but it’s good to do your research and talk to the veterinarian before giving anything to your dog.

And as always, I welcome your comments. I’d love to hear if you’ve had any experience using Trifexis as a flea treatment for your dog. Is Trifexis safe for dogs?

If you’re experiencing a hot summer, read How to Exercise Your Dog in Hot Weather.


May you find the best flea treatment for your dog by doing your research and talking to the right veterinarians.

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1 Response

  1. September 5, 2016

    […] And, my dog has a mild-to-severe stomach problems that took me almost two years to solve. My friend’s dog had tummy troubles that were actually caused by a flea treatment. If you’re giving your dog flea medication, read Is Trifexis a Safe Flea Treatment for Dogs? […]

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